UTMB’s David R. Marshall, Patricia Davis, Tammy Cupit, Timothy Hilt, Jennifer Baer and Barbara Bonificio write that 15 years have passed since Sorrells-Jones and Weaver authored a series of articles describing knowledge workers and knowledge-intense organizations. During the intervening years, progress has been made at UTMB. During this time, there have also been technological advances that make information and knowledge accessible to the clinician at the point of care, often via the use of hand-held devices, and there has been widespread adoption of electronic health records. This article describes UTMB’s journey toward the knowledge-intense future envisioned by Sorrells-Jones and Weaver that may prove useful to other organizations.